effect of zinc on efficacy of iron supplementation in improving iron and zinc status in women锌对补铁的效果在改善铁和锌在女性地位.pdfVIP

Hindawi Publishing Corporation Journal of Nutrition and Metabolism Volume 2012, Article ID 216179, 8 pages doi:10.1155/2012/216179 Research Article Effect of Zinc on Efficacy of Iron Supplementation in Improving Iron and Zinc Status in Women Phuong Nguyen,1 Ruben Grajeda,2 Paul Melgar,3 Jessica Marcinkevage,1 Rafael Flores,1, 4 Usha Ramakrishnan,1, 4 and Reynaldo Martorell1, 4 1 Nutrition and Health Sciences Program, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA 2 Micronutrient Program, Pan American Health Organization, Washington, DC 20037, USA 3 Institute of Nutrition of Central America and Panama, Calzada Roosevelt 6-25 Zona 11, Apartado Postal 1188, Guatemala City, Guatemala 4 Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA Correspondence should be addressed to Reynaldo Martorell, rmart77@ Received 30 January 2012; Accepted 10 March 2012 Academic Editor: Christel Lamberg-Allardt Copyright © 2012 Phuong Nguyen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Iron and zinc may interact in micronutrient supplements and thereby decrease efficacy. We investigated interactive effects of combined zinc and iron supplementation in a randomized controlled trial conducted in 459 Guatemalan women. Four groups were supplemented for 12 weeks: (1) weekly iron and folic acid (IFA); (2) weekly IFA and 30 mg zinc; (3) daily IFA; (4) daily IFA and 15 mg zinc. Effects were assessed by generalized linear regression. Baseline hemoglobin (Hb) concentration was 137.4 ± 15.5 g/L, 13% were anemic and 5