effect of high dose intravenous ascorbic acid on the level of inflammation in patients with rheumatoid arthritis高剂量静脉注射抗坏血酸对类风湿性关节炎患者的炎症水平.pdfVIP

下载本文档

6
0
约4.76万字
约 7页
2017-08-28 发布于上海
举报
版权申诉

effect of high dose intravenous ascorbic acid on the level of inflammation in patients with rheumatoid arthritis高剂量静脉注射抗坏血酸对类风湿性关节炎患者的炎症水平.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

effect of high dose intravenous ascorbic acid on the level of inflammation in patients with rheumatoid arthritis高剂量静脉注射抗坏血酸对类风湿性关节炎患者的炎症水平

Vol.1, No.2, 26-32 (2012) Modern Research in Inflammaion /10.4236/mri.2012.12004 Effect of high dose intravenous ascorbic acid on the level of inflammation in patients with rheumatoid arthritis * N. Mikirova , A. Rogers, J. Casciari, P. Taylor * Riordan Clinic, Wichita, USA; Corresponding Author: nmikirova@ Received 13 September 2012; revised 16 October 2012; accepted 14 November 2012 ABSTRACT cases. These treatments have limited success and may cause significant adverse effects. Alternative and com- Rheumatoid arthritis (RA) is a major inflamma- plementary medicine (CAM) approaches to arthritis in- tory joint disease that causes cartilage destruc- clude supplementation with gamma-linolenic acid, fish tion, bone erosions, and joint destruction. Oxi- oil (and/or omega 3 fatty acids), antioxidants (such as dative stress is elevated in RA patients implying vitamins C, E, quercetin, and lipoic acid), and dietary ad- reactive oxygen species (ROS) are possible justments [1]. So far, clinical studies testing these CAM mediators of tissue damage. ROS trigger a cas- therapies have not demonstrated significant benefits to cade of events through nuclear factors’ activa- RA patients [2-7]. tion (NF-kappa B), which up-regulates gene ex- RA is thought to be an autoimmune illness. Hallmarks pression of pro-inflammatory cytokines that of RA pathology include chronic inflammation