effects of telmisartan with hydrochlorothiazide versus valsartan with hydrochlorothiazide in patients with moderate-to-severe hypertension替米沙坦和氢氯噻嗪的影响与缬沙坦和氢氯噻嗪是严重高血压患者.pdfVIP

Hindawi Publishing Corporation International Journal of Hypertension Volume 2012, Article ID 976828, 7 pages doi:10.1155/2012/976828 Clinical Study Effects of Telmisartan with Hydrochlorothiazide versus Valsartan with Hydrochlorothiazide in Patients with Moderate-to-Severe Hypertension Ravi Marfatia,1 William B. White,1 and Helmut Schumacher2 1 Division of Hypertension and Clinical Pharmacology, Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, CT 06030, USA 2 Medical Data Services Department, Boehringer Ingelheim GmbH, Binger Straße 173, 5216 Ingelheim am Rhein, Germany Correspondence should be addressed to William B. White, wwhite@ Received 29 February 2012; Accepted 21 May 2012 Academic Editor: Thomas Unger Copyright © 2012 Ravi Marfatia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Combination therapy is recommended for patients with blood pressure (BP) significantly above goal by recent consensus guidelines around the globe. The use of angiotensin II receptor blockers (ARBs) alone or in combination with a thiazide diuretic is a preferred treatment strategy due to both efficacy and safety considerations. However, there are few data known about the benefits of ARB-diuretic combination therapy in patients with moderate-to-severe hypertension. We performed a subanalysis from two large clinical trials that compared the antihypertensive effects of telmisartan 80 mg versus valsartan 160 mg, both combined with hydrochlorothiazide (HCTZ) 25 mg in a subpopulation of 725 patients with moderate-to-severe hypertension (systolic BP SBP ≥ 160 mm Hg