原创力文档effects of walnut on lipid profile as well as the expression of sterol-regulatory element binding protein-1c(srebp-1c) and peroxisome proliferator activated receptors α (pparα) in diabetic rat英文论文.pdfVIP
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effects of walnut on lipid profile as well as the expression of sterol-regulatory element binding protein-1c(srebp-1c) and peroxisome proliferator activated receptors α (pparα) in diabetic rat英文论文
Food and Nutrition Sciences, 2012, 3, 255-259
/10.4236/fns.2012.32037 Published Online February 2012 (http://www.SciRP.org/journal/fns)
Effects of Walnut on Lipid Profile as Well as the
Expression of Sterol-Regulatory Element Binding
Protein-1c(SREBP-1c) and Peroxisome Proliferator
Activated Receptors α (PPARα) in Diabetic Rat
1* 2 1
Ebrahim Abbasi Oshaghi , Arash Noori Sorkhani , Ali Rezaei
1Department of Laboratory Science, Islamic Azad University, Borūjerd, Iran; 2Afzalipour School of Medicine, Kerman University of
Medical Sciences, Kerman, Iran.
*
Email: 7abbasi@
nd st th
Received November 2 , 2011; revised December 21 , 2011; accepted December 30 , 2011
ABSTRACT
Diabetes Mellitus has appeared as a universal burden. Studies have reported that mortality from Coronary Heart Disease
(CHD) in diabetic patients is 2 - 4 times higher than nondiabetics. In this respect, walnut is a treatment which has bene-
ficial effects on CHD risk factors. PPARα and SREBP-1c play an important role in the regulation of lipid metabolism.
This study was aimed to evaluate the effects of walnut on lipid profile as well as SREBP-1c and PPARα protein levels
in rats. Animals were randomly divided into 3 groups (n = 6); Group 1: Received chow only (control), Group 2: Diabetic
rats + chow, Group 3: Diabetic rats + chow supplemented with 4% of whole walnuts. After four weeks rats were sacrificed,
blood was collected; lipid profiles as well as SREBP-1c and PPARα protein levels were determined. Compared with
diabetic rats walnut significantly decreased serum cholesterol (P 0.01), LDL-c (P 0.01), triglyceride (P 0.001) and
VLDL-c (P 0.001) and also increased HDL-c (P 0.05) compared with diabetic. Moreover, SREBP-1c protein level
significantly decreased (P 0.05) and PPAR
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