长期小剂量红霉素口服治疗慢性支气管炎疗效观察.docVIP

长期小剂量红霉素口服治疗慢性支气管炎疗效观察作者单位：510800 广州市中西医结合医院 通讯作者：邹敏 【摘要】 目的 观察长期小剂量应用红霉素类抗生素治疗慢性支气管炎的临床疗效，总结其临床价值。方法 选取本院2008年12月～2010年12月140例慢性支气管炎患者，随机分为观察组和对照组各70例，对照组根据患者临床症状予抗感染及止咳、祛痰，解痉、平喘等对症治疗及增强免疫治疗，观察组在对照组的治疗基础上加用小剂量红霉素250 mg/d，长期口服，两组均临床观察1年，对比两组治疗效果，记录相关数据并进行统计学分析。结果 观察组显效56例，占80.00%，有效12例，占17.14%，无效2例，占2.86%，急性发作住院1次，总有效率97.14%；对照组显效37例，占52.86%，有效16例，占22.86%，无效17例，占24.29%，急性发作住院6次，总有效率75.71%，两组疗效比较差异有统计学意义（P0.05）。结论 长期小剂量应用红霉素口服治疗慢性支气管炎的临床疗效明显优于常规抗感染及对症治疗，且明显减少急性发作住院次数，不良反应较少，值得在临床上推广应用。 【关键词】 长期； 小剂量红霉素； 慢性支气管炎； 临床疗效 Long-term low-dose oral erythromycin treatment efficacy of chronic bronchitis ZOU Min, XIONG Cheng-wen, ZHANG Jun, XIAO Hui-zhen, CHEN Ren-shan. Guangzhou Hospital of Integrated Chinese and Western Medicine, Guangzhou 510800, China 【Abstract】 Objective To observe the long-term low-dose application of erythromycin antibiotics’s clinical efficacy for the treatment of chronic bronchitis, summarize its clinical value.Methods 140 cases of chronic bronchitis were randomly divided into two groups and 70 cases of the control group, the control group according to clinical symptoms in patients with resistance to infection and cough, phlegm, the solution spasm, asthma and other symptomatic treatment and enhanced the immune treatment, observation group was treated based on the use of low-dose erythromycin 250 mg/d, long-term oral, clinical observation in both groups a year, compared two groups of treatment effect observed, recorded relevant data for statistical analysis.Results The markedly effective in 56 cases, accounting for 80.00%, effective in 12 cases, accounting for 17.14%, 2 cases, accounting for 2.86%, acute hospital 1, the total effective rate 97.14%; the control group that were 37 cases, accounting for 52.86%, effective in 16 cases, accounting for 22.86%, ineffective in 17 cases, accounting for 24.29%, acute hospital six times, the total effective rate 75.71%, difference between the two groups was significant（P0.05）.Conclusion Long-term low-