大剂量激素对髋关节周围骨影响实验的研究.pdf

郑州人学2007届顿I：论文 人剂量激素对髋j∈节蒯丽骨影响的实验研究 1、大剂量甲强龙可以造成血清总胆固醇及甘油三酯均升高及脂肪肝。 2、大剂量甲强龙可以造成股骨头、股骨近端骨坏死。 3、大剂量甲强龙可以造成股骨头、髋臼、股骨近端骨组织内BMP．2表达降低， 激素的应用时间越长，应用总量越大，对其骨髓的影响越严重。 关键词 动物模型；股骨头缺血坏死；激素；血脂；骨形成蛋白一2 11| 郑州人学2007届颂l：论文 大剂量激素对髋关节周ff{骨影响的实验研究 An ontheeffectsof study glucocorticoid experimental on hipbone Yongle PostgraduateZhang Tutor WangYisheng of DepartmentOrthopaedics， TheFirstAffiliated of HospitalZhengzhouUniversity and Steroid—inducedOsteonecrosisoftheFemoral Backgroundpurpose beseen the is patient，itimportant Head(ONFH)canfrequentlyamongorthopaedics to the ofONFH．The oftotal studypathogenesis asepticloosing hipreplacement otherreason-inducedtotal more than ONFH，is hip (ALTHR)of frequently ONFHandtheeffectsof the ofsteroid-induced replaee(THR)．Tostudypathogenesis different of on ossisfemorisand acetabulum，caput dosagesmethylprednisolone femursinarabbitmodel of the BMP一2，discuss proximal byhistology,expression reasonofALTHR劬mthisdirection． MaterialsandMethods24ad