联合用药的药物相互作用及研究方法.PDF

- 276 - Drug Evaluation Research 第 37 卷 第 3 期 2014 年 6 月 联合用药的药物相互作用及研究方法 黄宇星，刘二伟* 天津中医药大学，天津 300193 摘 要：随着人们对于疾病的认识越来越深入，联合用药得到越来越普遍的使用，同时所产生的药物间的相互作用也越来越 受到关注。联合用药可能通过影响与药物吸收、分布、代谢、排泄等相关的酶、转运体等，以改变药物的药代属性（生物利 用度、分布特性等），调节体内动态药效物质组的构成，改变药物的药效（协同作用、拮抗作用、毒副作用等），从而对药物 的有效性、安全性产生影响。从联合用药对药物吸收与代谢的影响这两方面来阐述联合用药的研究近况，为联合用药的基础 研究以及临床应用的安全有效提供参考。 关键词：联合用药；药物相互作用；药物吸收；药物代谢；药动学；药效学 中图分类号：R969.2 文献标志码：A 文章编号：1674 - 6376 (2014) 03 - 0276 - 04 DOI: 10.7501/j.issn.1674-6376.2014.03.021 Drug interactions and research methods of drug combination HUANG Yu-xing, LIU Er-wei Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China Abstract: As people increasingly in-depth understanding of the disease, drug combination has been more widely used, and the generated interactions of drug combination have attracted more and more attention. Drug combination may impact the enzymes and transporters associated with drug absorption, distribution, metabolism, and excretion, so as to change the drug pharmacokinetics properties (bioavailability, distribution characteristics, etc), regulate the dynamic effective substance groups constituted in body, change the drug effect (synergism, antagonism, side effects, etc), and impact the efficacy and safety of drugs. Now this article explained the current research status of drug combination by summarizing the effects of drug combination on absorption and metabolism of drugs, in order to provide some reference to basic research and clinical application about drug combination. Key words: drug combination; drug interaction; drug absorption; drug metabolism; pharmacokinetic; pharmacodynamics 联合用药（drug combination ）是指为了达到治 联合用药所引起的药物相互作用可能使药物效 疗目的而采用的两种或两种以上药物同时或先后应 应改变，这种改