aberrant methylation inactivates transforming growth factor receptor i in head and neck squamous cell carcinoma转化生长因子受体异常甲基化灭活我在头颈部鳞状细胞癌.pdfVIP

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aberrant methylation inactivates transforming growth factor receptor i in head and neck squamous cell carcinoma转化生长因子受体异常甲基化灭活我在头颈部鳞状细胞癌.pdf

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aberrant methylation inactivates transforming growth factor receptor i in head and neck squamous cell carcinoma转化生长因子受体异常甲基化灭活我在头颈部鳞状细胞癌

Hindawi Publishing Corporation International Journal of Otolaryngology Volume 2009, Article ID 848695, 10 pages doi:10.1155/2009/848695 Research Article Aberrant Methylation Inactivates Transforming Growth Factor β Receptor I in Head and Neck Squamous Cell Carcinoma ˜ 1 2 3 1 Teresita Munoz-Antonia, Mariclara Torrellas-Ruiz, Jonathan Clavell, Linda A. Mathews, 4 ´ 3, 5 Carlos A. Muro-Cacho, and Adriana Baez 1 Department of Interdisciplinary Oncology, Moﬃ tt Cancer Center, Tampa, FL 33612, USA 2 Department of Pathology, LSU Health Sciences Center, New Orleans, LA 70112, USA 3 Department of Pharmacology, University of Puerto Rico School of Medicine, San Juan, PR 00936, USA 4 Pathology and Laboratory Medicine, James A. Haley Veterans’ Aﬀ airs Medical Center, Tampa, FL 33612, USA 5 Department of Otolaryngology, University of Puerto Rico School of Medicine, San Juan, PR 00936, USA ´ Correspondence should be addressed to Adriana Baez, adriana.baez@ Received 10 December 2008; Accepted 27 March 2009 Recommended by Alﬁo Ferlito Background. Alterations in TGF-β signaling are common in head and neck cancer (HNSCC). Mutations in TGF-β type II receptor (TβR-II ) occur frequently in HNSCC while TGF-β type I receptor (TβR-I ) mutations are rare, suggesting that other molecular alterations in the TGF-β pathway are likely. To identify abnormalities in TβR-I expression we analyzed 50 HNSCCs and correlated the results with clinical-pathologic features. Methods. Hypermethylation of