absence of multiple sclerosis and demyelinating diseases among lacandonians, a pure amerindian ethnic group in mexico缺乏lacandonians多发性硬化症和脱髓鞘疾病,纯粹在墨西哥美洲印第安人的民族.pdfVIP

Hindawi Publishing Corporation Multiple Sclerosis International Volume 2012, Article ID 292631, 4 pages doi:10.1155/2012/292631 Clinical Study Absence of Multiple Sclerosis and Demyelinating Diseases among Lacandonians, a Pure Amerindian Ethnic Group in Mexico 1 ´ 1 1 2 Jose Flores, Silvia Gonzalez, Ximena Morales, Petra Yescas, Adriana Ochoa,2 and Teresa Corona1 1 Neurodegenerative Diseases Laboratory, The National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877 Col. La Fama. Del. Tlalpan, CP 14269, Mexico City 14000, DF, Mexico 2 Genetics Laboratory, The National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877 Col. La Fama. Del. Tlalpan, CP 14269, Mexico City, DF, Mexico Correspondence should be addressed to Teresa Corona, coronav@unam.mx Received 5 June 2012; Revised 20 July 2012; Accepted 22 July 2012 Academic Editor: Jorge Correale Copyright © 2012 Jose Flores et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Multiple Sclerosis (MS) is a highly polymorphic disease characterized by different neurologic signs and symptoms. In MS, racial and genetic factors may play an important role in the geographic distribution of this disease. Studies have reported the presence of several protective alleles against the development of autoimmune disorders. In the case of MS, however, they help define MS as a complex disease, and confirm the importance of environmental agents as an independent variable not associated with ethnicity. We carried out an on-site epidemi