air pollution, oxidative stress, and alzheimers disease空气污染、氧化应激和阿尔茨海默氏症.pdfVIP

Hindawi Publishing Corporation Journal of Environmental and Public Health Volume 2012, Article ID 472751, 9 pages doi:10.1155/2012/472751 Review Article Air Pollution, Oxidative Stress, and Alzheimer’s Disease Paula Valencia Moulton1 and Wei Yang1, 2 1 The Environmental Sciences and Health Graduate Program, University of Nevada, Reno, NV 89557-0186, USA 2 School of Community Health Sciences, University of Nevada, Reno, NV 89557-0274, USA Correspondence should be addressed to Wei Yang, weiyang@ Received 18 September 2011; Accepted 3 January 2012 Academic Editor: Pam R. Factor-Litvak Copyright © 2012 P. V. Moulton and W. Yang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Alzheimer’s disease (AD) is the most common form of dementia affecting millions of people worldwide and will continue to affect millions more with population aging on the rise. AD causality is multifactorial. Known causal factors include genetic predisposition, age, and sex. Environmental toxins such as air pollution (AP) have also been implicated in AD causation. Exposure to AP can lead to chronic oxidative stress (OS), which is involved in the pathogenesis of AD. Whereas AP plays a role in AD pathology, the epidemiological evidence for this association is limited. Given the significant prevalence of AP exposure combined with increased population aging, epidemiological evidence for this link is important to consider. In this paper, we examine the existing evidence supporting the relationship between AP, OS, and AD and provide recommendations for future research on the population level, which will provide evidence