autoradiographic mapping of binding sites in the rhesus monkey brain using [carbonyl-11c]zolmitriptanautoradiographic映射结合位点的恒河猴大脑使用carbonyl-11c佐米曲坦.pdfVIP

Hindawi Publishing Corporation International Journal of Molecular Imaging Volume 2011, Article ID 694179, 6 pages doi:10.1155/2011/694179 Research Article Autoradiographic Mapping of 5-HT1B/1D Binding Sites in the Rhesus Monkey Brain Using [carbonyl-11C]zolmitriptan 1 2 3 1 1 ¨ ˚ Orjan Lindhe, ˚ ¨ Per Almqvist, Matts Kagedal, Sven-Ake Gustafsson, Mats Bergstrom, Dag Nilsson,3 and Gunnar Antoni4 1 Uppsala Imanet AB, GE Healthcare, P.O. Box 967, 751 09 Uppsala, Sweden 2 Department of Clinical Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden 3 AstraZeneca RD, 151 85 S¨odert¨alje, Sweden 4 Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Box 574, 75123 Uppsala, Sweden ¨ Correspondence should be addressed to Orjan Lindhe, orjan.lindhe@ Received 24 May 2011; Revised 11 August 2011; Accepted 12 August 2011 Academic Editor: Habib Zaidi ¨ Copyright © 2011 Orjan Lindhe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Zolmitriptan is a serotonin 5-HT1B/1D receptor agonist that is an effective and well-tolerated drug for migraine treatment. In a human positron emission tomography study, [11C]zolmitriptan crossed the bloo