aβ damages learning and memory in alzheimer’s disease rats with kidney-yang deficiencyaβ损害在阿尔茨海默病大鼠学习和记忆温缺乏症.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 132829, 9 pages doi:10.1155/2012/132829 Research Article Aβ Damages Learning and Memory in Alzheimer’s Disease Rats with Kidney-Yang Deficiency Dongmei Qi,1 Yongfa Qiao,2 Xin Zhang,1 Huijuan Yu,1 Bin Cheng,1 and Haifa Qiao1, 3, 4 1 Neuroscience Program, Shandong University of Traditional Chinese Medicine, Changqing University Park, Jinan 250355, China 2 Qingdao Haici Medical Group, 4 Renmin Road, Qingdao 266033, China 3 Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, 16 Nanxiaojie, Dongzhimeinei, Beijing 100700, China 4 Department of Biomedical Sciences, Florida State University College of Medicine, 1115 West Call Street, Tallahassee, FL 32306, USA Correspondence should be addressed to Haifa Qiao, haifa.qiao@ Received 9 January 2012; Accepted 18 February 2012 Academic Editor: Shi-Bing Su Copyright © 2012 Dongmei Qi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Previous studies demonstrated that Alzheimer’s disease was considered as the consequence produced by deficiency of Kidney essence. However, the mechanism underlying the symptoms also remains elusive. Here we report that spatial learning and memory, escape, and swimming capacities were damaged significantly in Kidney-yang deficiency rats. Indeed, both hippocampal Aβ40 and 42 increases in Kidney-yang deficiency contribute to the learning and memory impairments. Specifically, damage of synaptic plasticity is involved in the learning and memory impairment of Kidney-yang deficiency rats. We determined that th