bacopa monniera attenuates scopolamine-induced impairment of spatial memory in mice加强monniera变弱scopolamine-induced损伤小鼠的空间记忆.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 236186, 10 pages doi:10.1093/ecam/neq038 Original Article Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice Manish Kumar Saraf,1, 2 Sudesh Prabhakar,1 Krishan Lal Khanduja,3 and Akshay Anand1 1 Department of Neurology, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India 2 Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA 3 Department of Biophysics, Post Graduate Institute of Medical Education and Research, Chandigarh, India Correspondence should be addressed to Akshay Anand, akshay1anand@rediff Received 31 August 2009; Accepted 31 March 2010 Copyright © 2011 Manish Kumar Saraf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Scopolamine, an anticholinergic, is an attractive amnesic agent for discerning the action of candidate antiamnesic drugs. Bacopa monniera Linn (Syn. Brahmi) is one such antiamnesic agent that is frequently used in the ancient Indian medical system. We have earlier reported the reversal of diazepam-induced amnesia with B. monniera. In this study we wanted to test if scopolamine- induced impairment of spatial memory can also be ameliorated by B. monniera using water maze mouse model. The objective of study was to study the effect of B. monniera on scopolamine-induced amnesia. We employed Morris water maze scale to test the amnesic effect of scopolamine and its reversal by B. monniera. Rotarod test was conducted to screen muscle coordination activity of mice. Scopolamine si