role of bone marrow-derived monocytesmacrophages in the repair of mucosal damage caused by irradiation andor anticancer drugs in colitis model角色的骨骨髓来源monocytesmacrophages修复粘膜损伤引起的辐照和或抗癌药物在结肠炎模型.pdf

Hindawi Publishing Corporation Mediators of Inflammation Volume 2010, Article ID 634145, 11 pages doi:10.1155/2010/634145 Research Article Role of Bone Marrow-Derived Monocytes/Macrophages in the Repair of Mucosal Damage Caused by Irradiation and/or Anticancer Drugs in Colitis Model Junji Takaba,1, 2 Yuji Mishima,2 Kiyohiko Hatake,2 and Tadashi Kasahara1 1 Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, Japan 2 Department of Clinical Research, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo 135-0063, Japan Correspondence should be addressed to Tadashi Kasahara, kasahara-td@pha.keio.ac.jp Received 11 September 2010; Revised 18 November 2010; Accepted 7 December 2010 Academic Editor: Magdalena Klink Copyright © 2010 Junji Takaba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Mucosal damage is a common side effect of many cancer treatments, especially radiotherapy and intensive chemotherapy, which often induce bone marrow (BM) suppression. We observed that acetic acid- (AA-) induced mucosal damage in the colon of mice was worsened by simultaneous treatment with irradiation or 5-FU. However, irradiation 14 days prior to the AA treatment augmented the recovery from mucosal damage, suggesting that the recovery from BM suppression had an advantageous effect on the mucosal repair. In addition, BM transplantation also augmented the recovery from AA-induced mucosal damage. We further confirmed that transplanted BM-derived cells, particularly F4/80+ Gr1+