role of dietary long-chain polyunsaturated fatty acids in infant allergies and respiratory diseases饮食长链多不饱和脂肪酸在婴儿过敏和呼吸道疾病.pdf

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 730568, 8 pages doi:10.1155/2012/730568 Review Article Role of Dietary Long-Chain Polyunsaturated Fatty Acids in Infant Allergies and Respiratory Diseases Lynette P. Shek,1 Mary Foong-Fong Chong,2 Jia Yi Lim,2 Shu-E Soh,1, 3 and Yap-Seng Chong4 1 Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228 2 Singapore Institute for Clinical Sciences, Agency for Science, Technology and Researsh (A∗STAR), Brenner Centre for Molecular Medicine, Singapore 117609 3 Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597 4 Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore 119228 Correspondence should be addressed to Lynette P. Shek, lynette shek@.sg Received 18 May 2012; Revised 21 August 2012; Accepted 23 August 2012 ´ ´ Academic Editor: Candido Juarez-Rubio Copyright © 2012 Lynette P. Shek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Maternal nutrition has critical effects on the developing structures and functions of the fetus. Malnutrition during pregnancy can result in low birth weight and small for gestational age babies, increase risk for infection, and impact the immune system. Long- chain polyunsaturated fatty acids (PUFAs) have been reported to have immunomodulatory effects. Decreased c