role of leptin in the activation of immune cells瘦素的免疫细胞的激活作用.pdf

Hindawi Publishing Corporation Mediators of Inflammation Volume 2010, Article ID 568343, 8 pages doi:10.1155/2010/568343 Review Article Role of Leptin in the Activation of Immune Cells ´ ´ Patricia Fernandez-Riejos, Souad Najib, Jose Santos-Alvarez, Consuelo Martın-Romero, ´ ´ ´ ´ ´ Antonio Perez-Perez, Carmen Gonzalez-Yanes, and Vıctor Sanchez-Margalet Department of Clinical Biochemistry, Virgen Macarena University Hospital, University of Seville, Av. Dr. Fedriani 3, 41071 Seville, Spain ´ ´ Correspondence should be addressed to Vıctor Sanchez-Margalet, margalet@us.es Received 30 October 2009; Revised 15 January 2010; Accepted 23 January 2010 Academic Editor: Giuseppe Matarese ´ Copyright © 2010 Patricia Fernandez-Riejos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Adipose tissue is an active endocrine organ that secretes various humoral factors (adipokines), and its shift to production of proinflammatory cytokines in obesity likely contributes to the low-level systemic inflammation that may be present in metabolic syndrome-associated chronic pathologies such as atherosclerosis. Leptin is one of the most important hormones secreted by adipocytes, with a variety of physiological roles related to the control of met