serum il-18 is closely associated with renal tubulointerstitial injury and predicts renal prognosis in iga nephropathy血清的地震阻力指标受伤也许可以与肾密切相关并预测在iga肾病肾脏预后.pdf

serum il-18 is closely associated with renal tubulointerstitial injury and predicts renal prognosis in iga nephropathy血清的地震阻力指标受伤也许可以与肾密切相关并预测在iga肾病肾脏预后.pdf

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serum il-18 is closely associated with renal tubulointerstitial injury and predicts renal prognosis in iga nephropathy血清的地震阻力指标受伤也许可以与肾密切相关并预测在iga肾病肾脏预后

Hindawi Publishing Corporation Mediators of Inflammation Volume 2012, Article ID 728417, 9 pages doi:10.1155/2012/728417 Research Article Serum IL-18 Is Closely Associated with Renal Tubulointerstitial Injury and Predicts Renal Prognosis in IgA Nephropathy Beili Shi, Zhaohui Ni, Liou Cao, Minjie Zhou, Shan Mou, Qin Wang, Minfang Zhang, Wei Fang, Yucheng Yan, and Jiaqi Qian Renal Division, Renji Hospital, Shanghai Jiaotong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China Correspondence should be addressed to Zhaohui Ni, profnizh@126.com Received 23 August 2011; Revised 20 October 2011; Accepted 20 October 2011 Academic Editor: Philipp M. Lepper Copyright © 2012 Beili Shi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. IgA nephropathy (IgAN) was thought to be benign but recently found it slowly progresses and leads to ESRD eventually. The aim of this research is to investigate the value of serum IL-18 level, a sensitive biomarker for proximal tubule injury, for assessing the histopathological severity and disease progression in IgAN. Methods. Serum IL-18 levels in 76 IgAN patients and 36 healthy blood donors were measured by ELISA. We evaluated percentage of global and segmental sclerosis (GSS) and extent of tubulointerstitial damage (TID). The correlations between serum IL-18 levels with clinical, histopathological features and renal prognosis were evaluated. Results. The patients were 38.85 ± 10.95 years old, presented with 2.61 (1.43∼4.08) g/day proteinuria. Serum IL-18 levels were significantly elevated in IgAN patients. Baseline serum IL-18 levels were signi

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