serum il-33 levels are associated with liver damage in patients with chronic hepatitis c血清il-33水平与慢性丙型肝炎患者的肝损伤相关.pdf

Hindawi Publishing Corporation Mediators of Inflammation Volume 2012, Article ID 819636, 7 pages doi:10.1155/2012/819636 Research Article Serum IL-33 Levels Are Associated with Liver Damage in Patients with Chronic Hepatitis C Juan Wang,1 Pingwei Zhao,1 Hui Guo,1 Xiguang Sun,1 Zhenyu Jiang,1 Lijun Xu,1 Junyan Feng,1 Junqi Niu,2 and Yanfang Jiang1 1 Department of Central Laboratory, The Second Part of First Hospital, Jilin University, Changchun 130032, China 2 Department of Hepatology, First Hospital, Jilin University, Changchun 130032, China Correspondence should be addressed to Junqi Niu, junqiniu@ and Yanfang Jiang, yanfangjiang@ Received 23 August 2011; Revised 18 October 2011; Accepted 19 October 2011 Academic Editor: Giamila Fantuzzi Copyright © 2012 Juan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Interleukin-33 (IL-33) is associated with the development of Th2 responses. This study examined the potential role of IL-33 in the pathogenic process of chronic hepatitis C (CHC) in Chinese patients. The levels of serum IL-33 and sST2 in 154 patients with CHC, 24 with spontaneously resolved HCV (SR-HCV) infection and 20 healthy controls (HC), were analyzed by ELISA. The concentrations of serum IL-2, IFN-γ, TNF-α, IL-4, IL-6, and IL-10, HCV loads, ALT, AST, and HCV-Ab were measured. We found that the levels of serum IL-33 in CHC patients were significantly higher than those of SR-HCV and HC but decreased after treatment with interferon for 12 weeks. More importantly, the levels of serum IL-33 were correlated with the concentrations of ALT and AST in CHC patients. The levels of serum sST2, as a