silica matrix doped with calcium and phosphate by sol-gel溶胶-凝胶法二氧化硅矩阵掺杂钙和磷酸盐.pdfVIP

Advances in Bioscience and Biotechnology, 2010, 1, 200-207 ABB doi:10.4236/abb.2010.13028 Published Online August 2010 (http://www.SciRP.org/journal/abb/) Silica matrix doped with calcium and phosphate by sol-gel Lucimara C. Bandeira, Katia J. Ciuffi, Paulo S. Calefi, Eduardo J. Nassar* Universidade de Franca, Av. Dr. Armando Salles Oliveira 201 Pq. Universitário, Franca, Brazil. Email: ejnassar@unifran.br Received 21 April 2010; revised 7 May 2010; accepted 10 May 2010. ABSTRACT 1970s because of its good biocompatibility; however, its can be easily dissolved in the body fluid. Bioactive Silica matrices doped with calcium and phosphate at glasses are more satisfactory in this sense, since the for- various Ca/P molar ratios were prepared by the hy- mation of silica on their surface promotes crystallization drolytic sol-gel methodology. Tetraethylorthosilicate of apatite containing calcium and phosphate [6,7]. The (TEOS) was reacted with calcium ethoxide, in the formation of hydroxyapatite nanocrystals makes these presence of phosphoric acid as catalyst. Eu III ions glasses potentially useful biomaterials, because they were added to the resulting silica, in order to obtain promote a favorable environment for osteoconduction, structural information. The samples were dried at protein adhesion, and osteoblast proliferation [8]. 50ºC and characterized before and after contact with The combination of HA and CaCO3