selective changes in the α-adrenoceptor-mediated contraction in the senescent rat urinary bladder选择性的变化α-adrenoceptor-mediated衰老大鼠膀胱收缩.pdfVIP

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selective changes in the α-adrenoceptor-mediated contraction in the senescent rat urinary bladder选择性的变化α-adrenoceptor-mediated衰老大鼠膀胱收缩.pdf

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selective changes in the α-adrenoceptor-mediated contraction in the senescent rat urinary bladder选择性的变化α-adrenoceptor-mediated衰老大鼠膀胱收缩

Vol.4, Special Issue I, 743-749 (2012) Health /10.4236/health.2012.429115 Selective changes in the α-adrenoceptor-mediated contraction in the senescent rat urinary bladder * Tomomi Aita, Akira Ishihata , Akiko Yamada, Yumi Katano Division of Theoretical Nursing and Pathophysiology, Yamagata University School of Medicine, Yamagata, Japan; * Corresponding Author: ishihata@med.id.yamagata-u.ac.jp Received 30 July 2012; revised 28 August 2012; accepted 6 September 2012 ABSTRACT aging and affect the quality of life in elderly people [1]. The maximal voiding rate and the contractility of urinary The urinary bladder is innervated and function- bladder are decreased, and the uninhibited bladder con- ally regulated by the autonomic nervous system. traction is frequently observed in aged people [2]. How- In order to elucidate the mechanism of func- ever, the mechanism of the age-related changes in uri- tional changes in aged rat urinary bladder, we nary bladder function is not yet elucidated in detail. studied the influence of senescence on, 1) the The urinary bladder consists of two regions: bladder α-adrenergic contractile response to phenyle- body and bladder base (trigone). The urinary bladder is phrine in the urinary bladder body and trigone, 2) innervated and functionally regulated by sympathetic and the muscarinic contractile response to carba- parasympathetic nerves.