role of in asthma and nonasthmatic eosinophilic bronchitis的角色在哮喘和nonasthmatic嗜酸性支气管炎.pdf

Hindawi Publishing Corporation Mediators of Inflammation Volume 2012, Article ID 645383, 9 pages doi:10.1155/2012/645383 Review Article Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis Beatriz Sastre and Victoria del Pozo Immunology Department, IIS-Fundacion Jimenez Dıaz and CIBER of Respiratory Diseases, 28040 Madrid, Spain ´ ´ ´ Correspondence should be addressed to Victoria del Pozo, vpozo@fjd.es Received 14 November 2011; Revised 9 January 2012; Accepted 9 January 2012 Academic Editor: David Aronoff Copyright © 2012 B. Sastre and V. del Pozo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, respiratory system appears to be unique in that PGE2 has beneficial effects. We described that the difference in airway function observed in patients with eosinophilic bronchitis and asthma could be due to differences in PGE2 production. PGE2 present in induced sputum supernatant from NAEB patients decreases BSMC proliferation, probably due to simultaneous stimulation of EP2 and EP4 receptors with inhibitory activity. This protective effect of P