role of hsp90 in systemic lupus erythematosus and its clinical relevance一半在系统性红斑狼疮中的作用及其临床意义.pdf

Hindawi Publishing Corporation Autoimmune Diseases Volume 2012, Article ID 728605, 6 pages doi:10.1155/2012/728605 Review Article Role of Hsp90 in Systemic Lupus Erythematosus and Its Clinical Relevance Hem D. Shukla1 and Paula M. Pitha1, 2 1 Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA 2 Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Correspondence should be addressed to Hem D. Shukla, hshukla2@ Received 14 July 2012; Accepted 6 September 2012 Academic Editor: Kamal D. Moudgil Copyright © 2012 H. D. Shukla and P. M. Pitha. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Heat shock proteins (HSP) are a family of ubiquitous and phylogenically highly conserved proteins which play an essential role as molecular chaperones in protein folding and transport. Heat Shock Protein 90 (Hsp90) is not mandatory for the biogenesis of most proteins, rather it participate in structural maturation and conformational regulation of a number of signaling molecules and transcription factors. Hsp90 has been shown to play an important role in antigen presentation, activation of lymphocytes, macrophages, maturation of dendritic cells, and in the enhanceosome mediated induction of inflammation. Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with complex immunological and clinical manifestations. Dysregulated expression of Type I interferon α, activation of B cells and production of autoantibodies are hallmarks of SLE. The enhanced levels of Hsp90 were detected in the serum of SLE p