selecting representative ages for developmental changes of respiratory irregularities and hypoxic ventilatory response in rats选择代表时代发展变化的呼吸不规则和大鼠低氧通气反应.pdfVIP

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selecting representative ages for developmental changes of respiratory irregularities and hypoxic ventilatory response in rats选择代表时代发展变化的呼吸不规则和大鼠低氧通气反应.pdf

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selecting representative ages for developmental changes of respiratory irregularities and hypoxic ventilatory response in rats选择代表时代发展变化的呼吸不规则和大鼠低氧通气反应

Open Journal of Molecular and Integrative Physiology, 2011, 1, 1-7 OJMIP doi: 10.4236/ojmip.2011.11001 Published Online May 2011 (http://www.SciRP.org/journal/ojmip/). Selecting representative ages for developmental changes of respiratory irregularities and hypoxic ventilatory response in rats * Lalah M Niane , Aida Bairam Unité de Recherche en Périnatologie, Centre Hospitalier Universitaire de Québec, Hôpital Saint-François d’Assise, Département de Pédiatrie, Université Laval, Québec. * Email: lalah-malika.niane.1@ulaval.ca Received 9 April 2011; revised 26 April 2011; accepted 5 May 2011. ABSTRACT 1. INTRODUCTION Apnea frequency and the weak ventilatory response The respiratory control system evolves rapidly in new- to hypoxia are a major clinical correlates of the im- born mammals during the neonatal period. The major maturity of respiratory control system in preterm clinical correlates of the immaturity of this system are neonates. Rats are frequently used as model to study periodic breathing and apnea, particularly in preterm the respiratory control during development. However, neonates. Accordingly, apnea in preterm neonates is sys- little is known about the postnatal ages that best rep- tematically treated. The hypoxic ventilatory response resent these respiratory irregularities and the hy- (HVR) is regularly used to evaluate the immaturity of poxic ventilatory response. Using plethysmography, the respiratory control system. This response is not fully we assessed baseline minute venti