role of extracellular matrix-mediated interactions in thymocyte migration细胞外matrix-mediated交互在胸腺细胞迁移的作用.pdf

Develop.mental Immunology, 2000, Vol. 7(2-4), pp. 279-291 (C) 2000 OPA (OverseasPublishers Association) Reprints available directly from the publisher N.V. Published by license under the Photocopying permitted by license only Harwood Academic Publishers imprint, part of the Gordon and Breach Publishing Group. Printed in Malaysia Role of Extracellular Matrix-Mediated Interactions in Thymocyte Migration WILSON SAVINOa*, StRGIO RANTO DALMAUb and VIN[CIUS COTTA DEALMEIDA aLaboratory on Thymus Research, Department ofImmunology, Oswaldo Cruz Institute Oswaldo Cruz Foundation, Rio de Janeiro, Brazil bDepartment ofBiochemistry, Biology Institute, University of the State of Rio de Janeiro and Program of Experimental Medicine, Basic Research Center, National Cancer Institute, Rio de Janeiro, Brazil; and CLaboratory ofCell Biology, Department ofUltrastructure and Cell Biology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro Brazil Cell adhesion, migration, differentiation and survival or death is amongst a large spectrum of biological responses that can be elicited by ligation of extracellular matrix components to their corresponding receptors. As regards the physiology of the thymus, cell migration is a crucial event in the general process of T cell differentiation. Studies on the intrathymic distri- bution of EC