原创力文档slight respiratory irritation but not inflammation in mice exposed to (1→3)-β-d-glucan aerosols轻微的呼吸道刺激但不是炎症小鼠暴露于(1→3)-β-d-glucan气溶胶.pdf
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slight respiratory irritation but not inflammation in mice exposed to (1→3)-β-d-glucan aerosols轻微的呼吸道刺激但不是炎症小鼠暴露于(1→3)-β-d-glucan气溶胶
Research Communication
Mediators of Inflammation, 12(3), 139/ 146 (June 2003)
AIRWAY irritation effects after single and repeated Slight respiratory irritation but
inhalation exposures to aerosols of b-glucan (grifo-
lan) were investigated in mice. In addition, the effects not inflammation in mice exposed
on serum total immunoglobulin E (IgE) production /3)-b-D-glucan aerosols
to (1 0
and histopathological inflammation in the respira-
tory tract were studied. The b-glucan aerosols pro-
voked slight sensory irritation in the airways, but the
response was not concentration dependent at the 1,CA 1 2,3
A. Korpi , J.-P. Kasanen , V.-M. Kosma ,
levels studied. Slight pulmonary irritation was ob- R. Rylander4 and A.-L. Pasanen1
served after repeated exposures. No effect was found
on the serum total IgE levels, and no signs of
inflammation were seen in the airways 6 h after the
final exposure. The results suggest that, irrespective 1Department of Environmental Sciences, University of
of previous fungal sensitization of the animals, Kuopio, P.O. Box 1627, 70211 Kuopio, Finland;
inhaled b-glucan may cause symptoms of respiratory 2Department of Pathology and Forensic Medicine,
tract irritation but without apparent inflammation. University of Kuopio and Kuopio University Hospital,
Respiratory tract irritation reported after inhalation Kuopio, Finland; 3Department of Pathology, Tampere
of fungi may not be entirely attributed to b-glucan.
University Hospital and University
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