the use of fractal dimension analysis in estimation of blood vessels shape in transplantable mammary adenocarcinoma in wistar rats after photodynamic therapy combined with cysteine protease inhibitors英文论文.pdfVIP

Hindawi Publishing Corporation Computational and Mathematical Methods in Medicine Volume 2012, Article ID 793291, 6 pages doi:10.1155/2012/793291 Research Article The Use of Fractal Dimension Analysis in Estimation of Blood Vessels Shape in Transplantable Mammary Adenocarcinoma in Wistar Rats after Photodynamic Therapy Combined with Cysteine Protease Inhibitors 1 2 ´ 2 Kamil Jurczyszyn, Beata J. Osiecka, and Piotr Ziołkowski 1 Department of Dental Surgery, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland 2 Department of Pathomorphology, Wroclaw Medical University, Marcinkowskiego 1, 50-368 Wrocław, Poland Correspondence should be addressed to Kamil Jurczyszyn, kjurczysz@interia.pl Received 26 June 2012; Accepted 1 August 2012 Academic Editor: Facundo Ballester Copyright © 2012 Kamil Jurczyszyn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fractal dimension analysis (FDA) is modern mathematical method widely used to describing of complex and chaotic shapes when classic methods fail. The main aim of this study was evaluating the influence of photodynamic therapy (PDT) with cystein proteases inhibitors (CPI) on the number and morphology of blood vessels inside tumor and on increase of effectiveness of combined therapy in contrast to PDT and CPI used separately. Animals were divided into four groups: control, treated using only PDT, treated using only CPI and treated using combined therapy, PDT and CPI. Results showed that time of animal survival and depth of necrosis inside tu