卡托普利联合格列喹酮治疗糖尿病肾病临床观察.docVIP

卡托普利联合格列喹酮治疗糖尿病肾病临床观察[摘要] 目的：探讨卡托普利联合格列喹酮（糖适平）治疗糖尿病肾病的效果。方法：选择血压正常的糖尿病肾病患者90例，将其随机分为观察组与对照组，每组各45例，对照组采用格列喹酮控制血糖，观察组在对照组基础上加用卡托普利，对比两组空腹血糖、蛋白尿、血肌酐情况。结果：治疗前两组患者血糖、尿蛋白排泄率及血肌酐水平比较，差异无统计学意义（P＞0.05），治疗2个月后，两组空腹血糖、尿蛋白排泄量、血肌酐水平治疗后均显著下降，差异有高度统计学意义（P＜0.01），治疗后两组血糖比较，差异无统计学意义（P＞0.05），观察组尿蛋白排泄量及血肌酐水平显著低于对照组，差异有高度统计学意义（P＜0.01）。结论：卡托普利与格列喹酮联合应用对糖尿病肾病的治疗效果显著。 [关键词] 糖尿病肾病；卡托普利；格列喹酮 [中图分类号] R587.1 [文献标识码] A [文章编号] 1673-7210（2011）11（a）-091-02 Clinical observation of Captopril combined Gliquidone in the treatment of diabetic nephropathy FAN Limei, XU Likun, HE Qiuyuan, HU Chunling, LI Liqun Department of Internal Medicine, Maternal and Child Health Hospital in Guangdong Province, Guangzhou 510010, China [Abstract] Objective: To investigate the clinical effect of Captopril combined Gliquidone in the treatment of diabetic nephropathy (DN). Methods: 90 cases of patients with DN and normal blood pressure were selected and randomly divided into observation group and control group, with 45 cases in each group. Gliquidone was taken for controlling blood sugar in control group, Captopril was taken in observation group on basis of control group. The level of blood sugar, urine protein and urea nitrogen was contrasted between control group and observation group. Results: Before treatment, the differences of level of blood sugar, urine protein and urea nitrogen between control group and observation group were no significant (P＞0.05). 2 months after treatment, the level of blood sugar, urine protein and urea nitrogen decreased, the differences were highly significant (P＜0.01), the difference of the level of blood sugar between the two groups was no significant (P＞0.05), the level of urine protein and urea nitrogen were lower in observation group than those in control group, with highly significant differences (P＜0.01). Conclusion: Captopril combined with Gliquidone on DN can obtain better curative effect. [Key words] Diabetic nephropathy; Captopril; Gliquidone 糖尿病肾病（diabe