新丹参注射液对大鼠离体心脏缺血／再灌注损伤的 - 中国实验动物学报.doc

中国被毛孢和蝙蝠蛾拟青霉小鼠免疫功能调节作用的比较研究 傅惠英1，，寿旗扬，，，陈民利( （1. 浙江中医药大学；.浙江中医药大学动物实验研究中心，浙江 杭州 310053） 观察中国被毛孢小鼠中国被毛孢3.0g?kg-1中国被毛孢和蝙蝠蛾拟青霉可显著提高小鼠吞噬指数和半数溶血值（P0.01）、显著提高T、B淋巴细胞增殖能力（P0.01，P0.05P0.05），0.5-1.5g?kg-1中国被毛孢都能显著抑制小鼠耳廓肿胀（P0.01,P0.05），同时还能抑制脾脏和胸腺增大（P0.01,P0.05）。结论 中国被毛孢和蝙蝠蛾拟青霉均具有免疫调节作用，而中国被毛孢免疫抑制及增强天然免疫系统作用要优于蝙蝠蛾拟青霉，而对适应性免疫系统增强作用蝙蝠蛾拟青霉优于中国被毛孢。 关键词：中国被毛孢；；mmunomodulatory Function of Hirsutella sinensis and Paecilomyces hepiali in Mice Hui-ying FU1, Li-zong ZHANG 2, Qi-yang SHOU 2, Wei-min ZHOU 2, Jue TU 2, Min-li CHEN2 (1. The Second Clinical Medical College, Zhejiang Chinese Medical University. 2. Laboratory Animal Research Center, Zhejiang Chinese Medical University. Hangzhou 310053, China) Abstract: Objective Compare with the immunomodulatory function by Hirsutella sinensis and Paecilomyces hepiali in vivo. Method After the mice were administrated by Hirsutella sinensis and Paecilomyces hepiali.Observed carbon particle clearance function, delayed type hypersensitivity, hemolytic antibody, lymphocyte proliferation and NK cell activity in mice, and Cordyceps sinensis as a positive control. Result 3.0g?kg-1 Hirsutella sinensis and Paecilomyces hepiali can significantly improve the phagocyte index and half of hemolysis value (P0.01). 3.0g?kg-1 Hirsutella sinensis and Paecilomyces hepiali can significantly improve the T, B lymphocyte proliferation (P0.01, P0.05). 3.0g?kg-1 Hirsutella sinensis can significantly enhance the activity of NK cells (P0.05). 0.5-1.5g?kg-1 Hirsutella sinensis can significantly inhibit the ear edema in mice (P0.01, P0.05), at the same time 1.5g?kg-1 Hirsutella sinensis can inhibit the spleen and thymus increases(P0.01, P0.05).Conclusion Hirsutella sinensis and Paecilomyces hepiali have Immunomodulatory effects. Hirsutella sinensis.The Hirsutella sinensis were better than Paecilomyces hepiali in immunosuppression and enhance the role of the innate immune system.Paecilomyces hepiali were better than the Hirsutella sinensis in enhanced adaptive immune s