现代复苏时的药物应用（Drug use in modern resuscitation）.docVIP

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现代复苏时的药物应用（Drug use in modern resuscitation）.doc

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现代复苏时的药物应用（Drug use in modern resuscitation）

现代复苏时的药物应用（Drug use in modern resuscitation） Drug use in modern resuscitation In cardiopulmonary resuscitation, drug use is a very important aspect. It is a clinicians goal to select and apply drugs appropriately, make it play a greater role and reduce side effects. To this end, this review summarizes the drugs involved in the resuscitation process. 1 the role and targets of drug use in recovery 1) it is beneficial to improve the perfusion of organs; 2) it is beneficial to defibrillation; 3) to prevent the recurrence of malignant ventricular arrhythmias; (4) patients with extreme bradycardia or arrest increase the excitability and conduction of the myocardium and conduction tissue; 5) correct metabolic disturbances caused by cardiac arrest; 6) protect brain tissue. 2 routes of administration, 1-4. When CPR is chosen, the route of administration represents the time when the drug enters the central circulation and produces the effect. The so-called time effect, which is time, is the most concentrated manifestation of life. Peripheral vein, central vein, and intratracheal administration are the most common routes. In children, they are forbidden to be administered by bone marrow and given by intravenous injection. Other routes, such as intra anal delivery, seem impractical. 2.1 peripheral vein At CPR, it takes 1.5 to 3min for the elbow to reach the central circulation, but if diluted with the 20ml fluid, the bolus effect is similar to that of the central vein. It is recommended that large doses of saline be administered to avoid the use of 5% Glucose Injection, with the aim of avoiding hyperglycemia due to circulatory arrest. 2.2 central vein With peripheral intravenous administration compared to central vein administration can obtain fast effect and peak concentration, Kuhn with indigo blue markers showed the peak concentration is 30s in the femoral vein, peripheral vein administration is 90s. In animal models, it was found that the concentration of lidocaine delivere