绞股蓝皂苷对高脂血症大鼠脂代谢影响.docVIP

绞股蓝皂苷对高脂血症大鼠脂代谢影响摘要：目的 研究不同剂量的绞股蓝皂苷(Five leaf Gynostemma Herb Saponin，FGHS)对实验性高脂血症大鼠脂代谢的影响。方法 通过改良脂肪乳剂的配方制备SD大鼠高脂血症模型，应用绞股蓝皂苷20 mg/kg、36 mg/kg、65 mg/kg、117 mg/kg和210 mg/kg五个不同剂量组，观察大鼠血脂代谢的变化。结果 绞股蓝皂苷可明显抑制高脂血症大鼠血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇（LDL ________________________________________ C）的水平以及显著抑制肝体重比，同时绞股蓝皂苷210 mg/kg剂量组将谷丙转氨酶(ALT)含量从125.50 U/L±25.81 U/L降至89.25 U/L±28.41 U/L，并提高血清超氧化物歧化酶(SOD)的活性和下调丙二醛(MDA)的含量(P＜0.05)。结论 绞股蓝皂苷可以降低实验性高脂血症大鼠血脂，纠正肝脏损伤，抑制脂质过氧化，纠正实验性高脂血症引起的脂质代谢紊乱。 关键词：绞股蓝皂苷；高脂血症；脂质代谢 中图分类号：R589.2 R285.5 文献标识码：A 文章编号：1672 ________________________________________ 1349（2011）09 ________________________________________ 1081 ________________________________________ 03 Effect of Five Leaf Gynostemma Herb Saponin on Lipid Metabolism in Hyperlipidemia Rats Shen Nan，Xu Wenpin，Li Min，et al//Peking University Health Science Center(Beijing 100191) Abstract:Objective To investigate the effect of five leaf gynostemma herb saponin (FGHS) on lipid metabolism in hyperlipidemia rats.Methods The hyperlipidemia rat models were establish with modified high lipid food.FGHS was used with 20，36，65，117，and 210 mg/kg to trea the rat models.The effect of FGHS on the lipid was evaluated.Results FGHS significantly reduced the level of rat serum total cholesterol，triglyceride，and low density lipoprotein cholesterol，malondiadehyde (MDA) and hepatosomatic index.FGHS of 210 mg/kg decreased the level of alanine transaminase(ALT) from （125.50±25.81） U/L to （89.25±28.41） U/L，enhanced the activities of superoxide dismutase (SOD)，and inhibited the increase of MDA(P＜0.05).Conclusion FGHS might contribute to reduce hyperlipidemia，mend of liver damage，inhibit oxidative modification and correct experimental hyperlipidemia. Key words：five leaf gynostemma herb saponin；hyperlipidemia；lipid metabolism 绞股蓝为葫芦科植物绞股蓝（Gynostemma pentaphyllum Makino）的多年生落叶草质藤木。绞股蓝皂苷(Five leaf Gynostemma Herb Saponin，FGHS)是从绞股蓝中提取的有效成分群，具有降血脂、抗氧化等多种作用［1］。本研究旨在从绞股蓝调节血脂代谢。纠正肝脏损伤，抑制脂