血管加压素-肾上腺素联合纳洛酮在心肺复苏中应用.docVIP

血管加压素\肾上腺素联合纳洛酮在心肺复苏中应用[摘要] 目的：探讨血管加压素、肾上腺素联合纳洛酮在心肺复苏中的应用情况。方法：将我院进行心肺复苏的49例患者随机分为两组，对照组24例采用肾上腺素治疗，观察组25例采用血管加压素、肾上腺素联合纳洛酮治疗。结果：观察组总有效率明显高于对照组，自主意识恢复时间明显短于对照组，组间差异均有统计学意义（均P＜0.05）。结论：血管加压素、肾上腺素联合纳洛酮在心肺复苏中的应用效果满意，值得临床关注。 [关键词] 心肺复苏；血管加压素；肾上腺素；纳洛酮 [中图分类号] R605.974[文献标识码]B [文章编号]1673-7210（2010）11（c）-037－０2 Application of Vasopressin, Epinephrine and Naloxone in cardiopulmonary resuscitation SU Zhanjun, ZHANG Yannan, XU Feng (Department of Pharmacy, Maternal and Child Care Centers of Jiamusi City, Heilongjiang Province, Jiamusi 154002, China) [Abstract] Objective: To investigate the application situation of Vasopressin, Epinephrine and Naloxone in cardiopulmonary resuscitation. Methods: In our hospital 49 patients of cardiopulmonary resuscitation were randomly divided into two groups, 24 cases of control group were treated with Epinephrine, 25 cases of observation group were treated with Vasopressin, Epinephrine and Naloxone. Results: In the observation group, the total effective rate was significantly higher than the control group, the self-consciousness recovery time was shorter than the control group, the differences were statistically significant (all P＜0.05). Conclusion: Vasopressin, Epinephrine and Naloxone in cardiopulmonary resuscitation have satisfactory result and there are worthy of attention. [Key words] Cardiopulmonary resuscitation; Vasopressin; Epinephrine; Naloxone 心肺复苏即在呼吸或心跳停止情况下所作之急救，目的在于尽快挽救脑细胞在低氧状态下坏死（4 min以上开始造成脑损伤，10 min以上即造成脑部不可逆伤害），因此施救时机越快越好，患者苏醒越快越好[1-2]。笔者探讨血管加压素、肾上腺素联合纳洛酮在心肺复苏中的应用，现将临床资料总结报道如下： 1 资料与方法 1.1 一般资料 选择2009年6～11月在我院进行心肺复苏的患者49例，其中，男29例，女20例；年龄18～71岁，平均（43.6±3.4）岁；患者发生心跳呼吸骤停到入院进行抢救的时间最短2 min，最长27 min。其中心脏病突发19例，溺水7例，药物中毒6例，电击伤2例，其他意外事件15例。将患者随机分为观察组25例和对照组24例，两组患者的一般资料比较，差异无统计学意义（P＞0.05），具有可比性。 1.2 方法 所有患者进行初级心肺复苏术和吸氧，建立静脉通道，心电监护，液体支持。对照组采用肾上腺素治疗：首剂给予标准剂量的肾上腺素1 mg静推，以后每隔3 min重复上述剂量直至自主循环恢复。观察组采用血管加压素、肾上腺素联合纳洛酮治疗：首剂给予肾上腺素1 mg、血管加压素40 U静推，同时给予纳洛酮5 mg静推，以后每3分钟重复肾上腺素1 mg直至自主循环恢复，每30 分钟重复纳洛酮5 mg静推