antigen load and viral sequence diversification determine the functional profile of hiv-1–specific cd8+ t cells抗原和病毒序列确定多元化的功能概要hiv-1-specific cd8 + t细胞.pdfVIP

PLoS MEDICINE Antigen Load and Viral Sequence Diversification Determine the Functional Profile of þ T Cells HIV-1–Specific CD8 1 1 2 1 1 1 Hendrik Streeck , Zabrina L. Brumme , Michael Anastario , Kristin W. Cohen , Jonathan S. Jolin , Angela Meier , Chanson J. Brumme1 1 1 1 1,3 1* , Eric S. Rosenberg , Galit Alter , Todd M. Allen , Bruce D. Walker , Marcus Altfeld 1 Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Center for Disaster and Humanitarian Assistance Medicine, Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, 3 Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America Funding: This study was supported A B S T R A C T by the National Institutes of Health (RO1 AI50429) and Acute Infection Early Disease Research Network (U01 AI052403). In addition, HS is Background supported by the Deutscher þ Akademischer Austauschdiensts Virus-specific CD8 T lymphocytes play a key role in the initial reduction of peak viremia (DAAD). ZLB is supported by a during acute viral infections, but display signs of increasing dysfunction and exhaustion u