cardiac complications in patients with community-acquired pneumonia a systematic review and meta-analysis of observational studies社区获得性肺炎患者的心脏并发症观察性研究的系统回顾和荟萃分析.pdfVIP

Cardiac Complications in Patients with Community- Acquired Pneumonia: A Systematic Review and Meta- Analysis of Observational Studies 1,2 1,2 1,2 3 1,2 Vicente F. Corrales-Medina *, Kathryn N. Suh , Gregory Rose , Julio A. Chirinos , Steve Doucette , D. William Cameron1,2, Dean A. Fergusson1,2 1 Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada, 2 Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, 3 Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Abstract Background: Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality. CAP can trigger acute cardiac events. We sought to determine the incidence of major cardiac complications in CAP patients to characterize the magnitude of this problem. Methods and Findings: Two investigators searched MEDLINE, Scopus, and EMBASE for observational studies of immunocompetent adults with clinical and radiological evidence of CAP that reported any of the following: overall cardiac complications, incident heart failure, acute coronary syndromes (ACS), or incident cardiac arrhythmias occurring within 30 days of CAP diagnosis. At a minimum, studies had to establish enrolment procedures and inclusion and exclusion criteria, enrol their patients sequentially, and report the incidence of cardiac complications as a function of their entire cohorts. Studies with focus on nosocomial or health care–associated pneumonia were not included. Review of 2,176 citations yielded 25 articles that met eligibility and minimum quality criteria. Seventeen articles (68%) reported cohorts of CAP inpatients. In