brain potentials of conflict and error-likelihood following errorful and errorless learning in obsessive-compulsive disorder大脑潜力的冲突和error-likelihood errorful和无误学习强迫症.pdfVIP

Brain Potentials of Conflict and Error-Likelihood Following Errorful and Errorless Learning in Obsessive- Compulsive Disorder 1 2 3 2,5 ¨ 1,4 Anke Hammer *, Andreas Kordon , Marcus Heldmann , Bartosz Zurowski , Thomas F. Munte 1 Department of Neuropsychology, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany, 2 Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany, 3 Department of Neurology, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany, 4 Center for Behavioral Brain Sciences, Magdeburg, Germany, 5 Neuroimage Nord, University of Hamburg, Hamburg, Germany Abstract Background: The anterior cingulate cortex (ACC) is thought to be overacting in patients with Obsessive Compulsive Disorder (OCD) reflecting an enhanced action monitoring system. However, influences of conflict and error-likelihood have not been explored. Here, the error-related negativity (ERN) originating in ACC served as a measure of conflict and error- likelihood during memory recognition following different learning modes. Errorless learning prevents the generation of false memory candidates and has been shown to be superior to trial-and-error-learning. The latter, errorful learning, introduces false memory candidates which interfere with correct information in later recognition leading to enhanced conflict processing. Methodology/Principal Findings: Sixteen OCD patients according to DSM-IV criteria and 16 closely matched healthy controls participated voluntarily in the event-r