characterisation of clostridium difficile hospital ward–based transmission using extensive epidemiological data and molecular typing描述医院ward-based梭状芽胞杆菌的传播使用广泛的流行病学数据和分子类型.pdfVIP

Characterisation of Clostridium difficile Hospital Ward– Based Transmission Using Extensive Epidemiological Data and Molecular Typing 1,2. 1. 1 1,3 4 A. Sarah Walker *, David W. Eyre , David H. Wyllie , Kate E. Dingle , Rosalind M. Harding , Lily 1 1,5 1,5 1 6,7 1,5 O’Connor , David Griffiths , Ali Vaughan , John Finney , Mark H. Wilcox , Derrick W. Crook , Tim E. A. Peto1,5, on behalf of the Infections in Oxfordshire Research Database 1 National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, 2 Medical Research Council Clinical Trials Unit, London, United Kingdom, 3 Nuffield Department of Clinical Laboratory Sciences, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom, 4 Department of Zoology, Oxford University, Oxford, United Kingdom, 5 Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom, 6 Department of Microbiology, The General Infirmary, Old Medical School, Leeds, United Kingdom, 7 Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom Abstract Background: Clostridium difficile infection (CDI) is a leading cause of antibiotic-associated diarrhoea and is endemic in hospitals, hindering the identification of sources and routes of transmission based on shared time and space alone. This may compromise rational control despite costly prevention strategies. This study aimed to investigate ward-based transmission of C. difficile, by subdividing outbreaks into di