cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish心脏肥大是肌细胞肥大和增生斑马鱼乏力.pdfVIP

Cardiac Hypertrophy Involves Both Myocyte Hypertrophy and Hyperplasia in Anemic Zebrafish 1,2. 1,2. 3 1,2 1,2,4 1,2 Xiaojing Sun , Tiffany Hoage , Ping Bai , Yonghe Ding , Zhenyue Chen , Ruilin Zhang , Wei 1,2 2 5 3 1,2 Huang , Ashad Jahangir , Barry Paw , Yi-Gang Li , Xiaolei Xu * 1 Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America, 2 Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Minnesota, United States of America, 3 Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 4 Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 5 Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America Abstract Background: An adult zebrafish heart possesses a high capacity of regeneration. However, it has been unclear whether and how myocyte hyperplasia contributes to cardiac remodeling in response to biomechanical stress and whether myocyte hypertrophy exists in the zebrafish. To address these questions, we characterized the zebrafish mutant tr265/tr265, whose Band 3 mutation disrupts erythrocyte formation and results in anemia. Although Band 3 does not express and function in the heart, the chronic anemia imposes a sequential biomechanical stress towards the heart. Methodology/Principal Findings: Hearts of the tr265/tr265 Danio rerio mutant become larger than those of the sibling by week 4 post fertilization and gradually exhibit characteristics of human cardiomyopathy, such as