原创力文档cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials胆碱能配对与视觉激活导致长期增强视觉诱发电位.pdfVIP
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cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials胆碱能配对与视觉激活导致长期增强视觉诱发电位
Cholinergic Pairing with Visual Activation Results in
Long-Term Enhancement of Visual Evoked Potentials
Jun Il Kang, Elvire Vaucher*
´ ´ ´ ´ ´
Ecole d’optometrie, Universite de Montreal, Montreal, Quebec, Canada
Abstract
Acetylcholine (ACh) contributes to learning processes by modulating cortical plasticity in terms of intensity of neuronal
activity and selectivity properties of cortical neurons. However, it is not known if ACh induces long term effects within the
primary visual cortex (V1) that could sustain visual learning mechanisms. In the present study we analyzed visual evoked
potentials (VEPs) in V1 of rats during a 4–8 h period after coupling visual stimulation to an intracortical injection of ACh
analog carbachol or stimulation of basal forebrain. To clarify the action of ACh on VEP activity in V1, we individually pre-
injected muscarinic (scopolamine), nicotinic (mecamylamine), a7 (methyllycaconitine), and NMDA (CPP) receptor
antagonists before carbachol infusion. Stimulation of the cholinergic system paired with visual stimulation significantly
increased VEP amplitude (56%) during a 6 h period. Pre-treatment with scopolamine, mecamylamine and CPP completely
abolished this long-term enhancement, while a7 inhibition induced an instant increase of VEP amplitude. This suggests a
role of ACh in facilitating visual stimuli responsiveness through mechanisms comparable to LTP which involve nicotinic and
muscarinic receptors with an interaction of NMDA transmission in the visual cortex.
Citation: Kang JI, Vaucher E (2009) Cholinergic Pairing with Visual Activation Results in Long-Term Enhancement of Visual Evoked Potentials. PLoS ONE 4(6):
e5995. doi:10.1371/journal.pone.0005995
Editor: Teresa Serrano-Gotarredona, National Microelectronics Center, S
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