comparative sequence and structural analyses of g-protein-coupled receptor crystal structures and implications for molecular models比较序列和结构分析g-protein-coupled受体的晶体结构和分子模型的影响.pdfVIP

Comparative Sequence and Structural Analyses of G-Protein-Coupled Receptor Crystal Structures and Implications for Molecular Models Catherine L. Worth, Gunnar Kleinau, Gerd Krause* ¨ Leibniz-Institut fur Molekulare Pharmakologie (FMP), Berlin, Germany Abstract Background: Up until recently the only available experimental (high resolution) structure of a G-protein-coupled receptor (GPCR) was that of bovine rhodopsin. In the past few years the determination of GPCR structures has accelerated with three new receptors, as well as squid rhodopsin, bein