copd and the risk of tuberculosis - a population-based cohort study慢性阻塞性肺病和肺结核的风险u2014u2014以人群为基础的队列研究.pdfVIP

COPD and the Risk of Tuberculosis - A Population-Based Cohort Study 1,2 3,4 ¨ 5 1 6 Malin Inghammar *, Anders Ekbom , Gunnar Engstrom , Bengt Ljungberg , Victoria Romanus , ¨ ¨ 2, Arne Egesten2 Claes-Goran Lofdahl 1 Section for Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund University Hospital, Lund, Sweden, 2 Section for Respiratory Medicine, Department of Clinical Sciences Lund, Lund University, Lund University Hospital, Lund, Sweden, 3 Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute and Hospital, Stockholm, Sweden, 4 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, 5 Department of Clinical Sciences Malmo, Lund University, Malmo University Hospital, Malmo, Sweden, 6 Swedish Institute for Infectious Disease Control, Stockholm, Sweden Abstract Background: Both chronic obstructive pulmonary disease (COPD) and tuberculosis (TB) primarily affect the lungs and are major causes of morbidity and mortality worldwide. COPD and TB have common risk factors such as smoking, low socioeconomic status and dysregulation of host defence functions. COPD is a prevalent co-morbid condition, especially in elderly with TB but in contrast to other diseases known to increase the risk of TB, relatively little is known about the specific relationship and impact from COPD on TB-incidence and mortality. Methods and Findings: All individuals $40 years of age, discharged with a diagnosis of COPD from Swedish hospitals 1987–2003 were identified in the Swedish Inpatient Register (n = 115,867). Records were linked to the Swe