delivery of a small for gestational age infant and greater maternal risk of ischemic heart disease交付的一个小胎龄婴儿和产妇缺血性心脏病的风险.pdfVIP

Delivery of a Small for Gestational Age Infant and Greater Maternal Risk of Ischemic Heart Disease 1 2 3 Radek Bukowski *, Karen E. Davis , Peter W. F. Wilson 1 Medical Branch, Department of Obstetrics and Gynecology, University of Texas, Galveston, Texas, United States of America, 2 Agency for Healthcare Research and Quality, Rockville, Maryland, United States of America, 3 Cardiology Division, Department of Medicine, School of Medicine, Atlanta VA Medical Center, Emory Clinical Cardiovascular Research Institute, Emory University, Atlanta, Georgia, United States of America Abstract Background: Delivery of a small for gestational age (SGA) infant has been associated with increased maternal risk of ischemic heart disease (IHD). It is uncertain whether giving birth to SGA infant is a specific determinant of later IHD, independent of other risk factors, or a marker of general poor health. The purpose of this study was to investigate the association between delivery of a SGA infant and maternal risk for IHD in relation to traditional IHD risk factors. Methods and Findings: Risk of maternal IHD was evaluated in a population based cross-sectional study of 6,608 women with a prior live term birth who participated in the National Health and Nutrition Examination Survey (1999–2006), a probability sample of the U.S. population. Sequence of events was determined from age at last live birth and at diagnosis of IHD. Delivery of a SGA infant is strongly associated with greater maternal risk for IHD (age adjusted OR; 95% CI: 1.8; 1.2, 2.9; p = 0.012). The association was independent of the family history of IHD, stroke, hypertension and diabetes (family history- adjusted OR; 95% CI: 1.9; 1.2, 3.0; p = 0.011) as w