detection of microrna expression in human peripheral blood microvesicles检测微rna表达在人类外周血微泡.pdfVIP
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detection of microrna expression in human peripheral blood microvesicles检测微rna表达在人类外周血微泡
Detection of microRNA Expression in Human Peripheral
Blood Microvesicles
1. 1,2. 3 4 5 3
Melissa Piper Hunter , Noura Ismail , Xiaoli Zhang , Baltazar D. Aguda , Eun Joo Lee , Lianbo Yu ,
6 1 7 5 1
Tao Xiao , Jeffrey Schafer , Mei-Ling Ting Lee , Thomas D. Schmittgen , S. Patrick Nana-Sinkam , David
Jarjoura3, Clay B. Marsh1,2*
1 Division of Pulmonary, Allergy, Critical Care, Sleep Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, 2 Molecular,
Cellular, Developmental Biology Program, College of Biological Sciences, The Ohio State University, Columbus, Ohio, United States of America, 3 Center for Biostatistics,
College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, 4 Mathematical Biosciences Institute, College of Medicine, The Ohio State
University, Columbus, Ohio, United States of America, 5 College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America, 6 Biostatistics, College
of Public Health, The Ohio State University, Columbus, Ohio, United States of America, 7 Department of Epidemiology and Biostatistics, University of Maryland, College
Park, Maryland, United States of America
Abstract
Background: MicroRNAs (miRNA) are small non-coding RNAs that regulate translation of mRNA and protein. Loss or
enhanced expression of miRNAs is associated with several diseases, including cancer. However, the identification of
circulating miRNA in healthy donors is not well characterized. Microvesicles, also known as exosomes or micro
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