原创力文档developmental hippocampal neuroplasticity in a model of nicotine replacement therapy during pregnancy and breastfeeding尼古丁替代疗法的发展模型中海马神经可塑性在怀孕和母乳喂养.pdfVIP
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developmental hippocampal neuroplasticity in a model of nicotine replacement therapy during pregnancy and breastfeeding尼古丁替代疗法的发展模型中海马神经可塑性在怀孕和母乳喂养
Developmental Hippocampal Neuroplasticity in a Model
of Nicotine Replacement Therapy during Pregnancy and
Breastfeeding
1 1 1 2 2
Ian Mahar , Rosemary C. Bagot , Maria Antonietta Davoli , Sharon Miksys , Rachel F. Tyndale , Claire-
1 1 3 1,4 1
Dominique Walker , Marissa Maheu , Sheng-Hai Huang , Tak Pan Wong *, Naguib Mechawar *
´
1 Departments of Psychiatry, Neurology and Neurosurgery, Douglas Mental Health University Institute, McGill University, Verdun, Quebec, Canada, 2 Departments of
Pharmacology and Toxicology and Psychiatry, Centre for Addiction and Mental Health and University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada,
3 Department of Microbiology, College of Basic Medicine, Anhui Medical University, Hefei, Anhui, People’s Republic of China, 4 Department of Pharmacology
´
Therapeutics, Douglas Mental Health University Institute, McGill University, Verdun, Quebec, Canada
Abstract
Rationale: The influence of developmental nicotine exposure on the brain represents an important health topic in light of
the popularity of nicotine replacement therapy (NRT) as a smoking cessation method during pregnancy.
Objectives: In this study, we used a model of NRT during pregnancy and breastfeeding to explore the consequences of
chronic developmental nicotine exposure on cerebral neuroplasticity in the offsp
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