diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic a case control study糖尿病与高血压的危险因素为成年登革出血热主要在登革热流行血清型2病例对照研究.pdfVIP

Diabetes with Hypertension as Risk Factors for Adult Dengue Hemorrhagic Fever in a Predominantly Dengue Serotype 2 Epidemic: A Case Control Study 1,2 2 2,3 1,2 2 4,5 Junxiong Pang *, Agus Salim , Vernon J. Lee , Martin L. Hibberd , Kee Seng Chia , Yee Sin Leo , David C. Lye4,5 1 Infectious Diseases, Genome Institute of Singapore, Singapore, Singapore, 2 Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, 3 Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore, 4 Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore, 5 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore Abstract Background: Dengue hemorrhagic fever (DHF) is a severe form of dengue, characterized by bleeding and plasma leakage. A number of DHF risk factors had been suggested. However, these risk factors may not be generalized to all populations and epidemics for screening and clinical management of patients at risk of developing DHF. This study explored demographic and comorbidity risk factors for DHF in adult dengue epidemics in Singapore in year 2006 (predominantly serotype 1) and in year 2007–2008 (predominantly serotype 2). Methods: A retrospective case-control study was conducted with 149 DHF and 326 dengue fever (DF) patients from year 2006, and 669 DHF and 1,141 DF patients from year 2007–2008. Demographic and reported comorbidity data were collected from patients previously. We performed multivariate logistic regression to assess the association between DHF and demographic and co-morbidities for year 2006 and year 2007–200