原创力文档differential changes in qtc duration during in-hospital haloperidol use微分时间改变高职院校学前教育专业在住院期间使用氟哌啶醇.pdfVIP
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differential changes in qtc duration during in-hospital haloperidol use微分时间改变高职院校学前教育专业在住院期间使用氟哌啶醇
Differential Changes in QTc Duration during In-Hospital
Haloperidol Use
1 1 2,3 1
Marieke T. Blom , Abdennasser Bardai , Barbara C. van Munster , Mei-Ing Nieuwland , Hendrik de
1 1 1 4 2,3
Jong , Daniel A. van Hoeijen , Anne M. Spanjaart , Anthonius de Boer , Sophia E. de Rooij , Hanno L.
Tan1*
1 Heart Failure Research Center, Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, 2 Department of Clinical
Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands, 3 Department of Internal Medicine and
Geriatrics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands, 4 Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht
Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Abstract
Aims: To evaluate changes in QT duration during low-dose haloperidol use, and determine associations between clinical
variables and potentially dangerous QT prolongation.
Methods: In a retrospective cohort study in a tertiary university teaching hospital in The Netherlands, all 1788 patients
receiving haloperidol between 2005 and 2007 were studied; ninety-seven were suitable for final analysis. Rate-corrected QT
duration (QTc) was measured before, during and after haloperidol use. Clinical variables before haloperidol use and at the
time of each ECG recording were retrieved from hospital charts. Mixed model analysis was used to estimate changes in QT
duration. Risk facto
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