discovery and analysis of evolutionarily conserved intronic splicing regulatory elements发现和分析进化保守intronic拼接监管元素.pdfVIP

Discovery and Analysis of Evolutionarily Conserved Intronic Splicing Regulatory Elements Gene W. Yeo1,2*, Eric L. Van Nostrand1,2¤, Tiffany Y. Liang1,2 1 Crick-Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, United States of America, 2 Laboratory of Genetics, Salk Institute, La Jolla, California, United States of America Knowledge of the functional cis-regulatory elements that regulate constitutive and alternative pre-mRNA splicing is fundamental for biology and medicine. Here we undertook a genome-wide comparative genomics a