dissociation between brain amyloid deposition and metabolism in early mild cognitive impairment脑淀粉样蛋白沉积和新陈代谢之间的分裂早期的轻度认知障碍.pdfVIP

Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment Liyong Wu1,2,3, Jared Rowley1,2, Sara Mohades1,2, Antoine Leuzy1,2, Marina Tedeschi Dauar1,2, 1,2 4 3 2 1,2,4 Monica Shin , Vladimir Fonov , Jianping Jia , Serge Gauthier , Pedro Rosa-Neto *, the Alzheimer’s Disease Neuroimaging Initiative 1Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, Quebec, Canada, 2 McGill Centre for Studies in Aging, McGill University, Montreal, Quebec, Canada, 3 Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China, 4 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada Abstract Background: The hypothetical model of dynamic biomarkers for Alzheimer’s disease (AD) describes high amyloid deposition and hypometabolism at the mild cognitive impairment (MCI) stage. However, it remains unknown whether brain amyloidosis and hypometabolism follow the same trajectories in MCI individuals. We used the concept of early MCI (EMCI) and late MCI (LMCI) as defined by the Alzheimer’s disease Neuroimaging Initiative (ADNI)-Go in order to compare the biomarker profile between EMCI and LMCI. Objectives: To examine the global and voxel-based neocortical amyloid burden and metabolism among individuals who are cognitively normal (CN), as well as those with EMCI, LMCI and mild AD. Methods: In the present study, 354 participants, including CN (n = 109), EMCI (n = 157), LMCI (n = 39) and AD (n = 49), were enrolled between September 2009 and November 2011 through ADNI-GO and ADNI-2. Brain amyloid load and metabolism we