distinct signature of altered homeostasis in aging rod photoreceptors implications for retinal diseases不同的签名改变老化杆感光细胞的动态平衡对视网膜疾病的影响.pdfVIP

Distinct Signature of Altered Homeostasis in Aging Rod Photoreceptors: Implications for Retinal Diseases 1.¤a 1,2. 2,3.¤b 1 1,2 Sunil K. Parapuram , Radu I. Cojocaru , Jessica R. Chang , Ritu Khanna , Matthew Brooks , 1 1¤c 1 2 2 Mohammad Othman , Sepideh Zareparsi , Naheed W. Khan , Norimoto Gotoh , Tiziana Cogliati , Anand Swaroop1,2* 1 Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America, 2 Neurobiology Neurodegeneration Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America, 3 Howard Hughes Medical Institute-National Institutes of Health Research Scholars Program, Bethesda, Maryland, United States of America Abstract Background: Advanced age contributes to clinical manifestations of many retinopathies and represents a major risk factor for age-related macular degeneration, a leading cause of visual impairment and blindness in the elderly. Rod photoreceptors are especially vulnerable to genetic defects and changes in microenvironment, and are among the first neurons to die in normal aging and in many retinal degenerative diseases. The molecular mechanisms underlying rod photoreceptor vulnerability and potential biomarkers of the aging process in this highly specialized cell type are unknown. Methodology/Principal Findings: To discover aging-associated adaptations that