dopamine genes (drd2ankk1-taqa1 and drd4-7r) and executive function their interaction with obesity多巴胺基因(drd2ankk1-taqa1和drd4-7r)和执行功能与肥胖.pdfVIP

Dopamine Genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and Executive Function: Their Interaction with Obesity 1,2,3 3,4 1,2,3 1 5 Mar Ariza , Maite Garolera *, Maria Angeles Jurado , Isabel Garcia-Garcia , Imma Hernan , ´ 6 7 7 1 Consuelo Sanchez-Garre , Maria Vernet-Vernet , Maria Jose Sender-Palacios , Idoia Marques-Iturria , Roser Pueyo1,2,3, Barbara Segura1,3, Ana Narberhaus1,2,3 1 Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain, 2 Institute for Brain, Cognition and Behaviour (IR3C), Barcelona, Spain, 3 Grup de Recerca Consolidat en Neuropsicologia (SGR0941), Barcelona, Spain, 4 Neuropsychology Unit, Deparment of Psychiatry, Hospital de Terrassa-Consorci Sanitari de Terrassa, Terrasa, Spain, 5 Molecular Genetics Unit, Hospital de Terrassa-Consorci Sanitari de Terrassa, Terrasa, Spain, 6 Pediatric Endocrinology Unit, Department of Pediatrics, Hospital de Terrassa-Consorci Sanitari de Terrassa, Terrassa, Spain, 7 CAP Terrassa Nord, Consorci Sanitari de Terrassa, Terrassa, Spain Abstract Obesity is a multifactorial disease caused by the interaction between genotype and environment, and it is considered to be a type of addictive alteration. The A1 allele of the DRD2/ANKK1-TaqIA gene has been associated with addictive disorders, with obesity and with the performance in executive functions. The 7 repeat allele of the DRD4 gene has likewise been associated with the performance in executive functions, as well as with addictive behaviors and im