dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes解剖饮食限制识别的基因网络的进化途径和新的功能基因.pdfVIP

Dissecting the Gene Network of Dietary Restriction to Identify Evolutionarily Conserved Pathways and New Functional Genes 1 2 1 1 1¤ 1 3 Daniel Wuttke , Richard Connor , Chintan Vora , Thomas Craig , Yang Li , Shona Wood , Olga Vasieva , 4,5 2 ˜ ˜ 1 Robert Shmookler Reis , Fusheng Tang *, Joao Pedro de Magalhaes * 1 Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom, 2 Department of Biology, University of Arkansas, Little Rock, Arkansas, United States of America, 3 Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom, 4 Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, 5 Department of Geriatrics and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America Abstract Dietary restriction (DR), limiting nutrient intake from diet without causing malnutrition, delays the aging process and extends lifespan in multiple organisms. The conserved life-extending effect of DR suggests the involvement of fundamental mechanisms, although these remain a subject of debate. To help decipher the life-extending mechanisms of DR, we first compiled a list of genes that if genetically altered disrupt or prevent the life-extending effects of DR. We called these DR– essential genes and identified more than 100 in model organisms such as yeast, worms, flies, and mice. In order for other researchers