differential expression of salivary proteins between susceptible and insecticide-resistant mosquitoes of culex quinquefasciatus唾液蛋白质的差异表达这种致倦库蚊的敏感和insecticide-resistant蚊子之间.pdfVIP

Differential Expression of Salivary Proteins between Susceptible and Insecticide-Resistant Mosquitoes of Culex quinquefasciatus 1 . 2. 2 3 3 Innocent Djegbe * , Sylvie Cornelie , Marie Rossignol , Edith Demettre , Martial Seveno , Franck Remoue1,2, Vincent Corbel1,2 ´ ´ ´ ˆ 1 Institut de Recherche pour le Developpement (IRD), Maladies Infectieuses et Vecteurs, Ecologie, Genetique, Evolution et Controle (MIVEGEC), UM1-CNRS 5290-IRD 224, ´ ´ Centre de Recherche Entomologique de Cotonou (CREC), Cotonou, Benin, 2 Institut de Recherche pour le Developpement (IRD), MIVEGEC, UM1-CNRS 5290-IRD 224, ´ Laboratoire de lutte contre les Insectes Nuisibles (LIN), Centre IRD, Montpellier, France, 3 Plate-forme de Proteomique Fonctionnelle, IGF, CNRS- UMR 5203, INSERM U661, ´ Universite Montpellier I et II, Montpellier, France Abstract Background: The Culex quinquefasciatus mosquito, a major pest and vector of filariasis and arboviruses in the tropics, has developed multiple resistance mechanisms to the main insecticide classes currently available in public health. Among them, the insensitive acetylcholinesterase (ace-1R allele) is widespread worldwide and confers cross-resistance to organophos- phates and carbamates. Fortunately, in an insecticide-free environment, this mutation is associated with a severe genetic cost that can affect various life histor